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Continuum-based
computational models for cell and nuclear mechanics
Ashkan Vaziri, Arvind Gopinath and Vikram S. Deshpande |
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Vol. 2 (2007), No. 6, 1169–1191
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Abstract |
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Deciphering the relationship between cellular processes and the structure of living cells is a key step toward understanding and predicting cell functions with direct implications for understanding human health and disease. The active nature of these cellular processes, which span several decades of spatial and temporal scales, pose significant challenges to unraveling this complex structure-function paradigm. Complementing novel experimental techniques with robust computational approaches capable of modeling mechanical response at varying scales provides new avenues to resolving this paradigm. We provide an overview of continuum-based computational approaches used in studying and interpreting responses of individual cells and nuclei, we outline techniques used for measuring the mechanical characteristics of living cells, and we discuss some of the key insights provided by these approaches. |
Keywords
cell mechanics, nuclear mechanics, computational mechanics
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Milestones
Received: 16 February 2007
Accepted: 24 February 2007
Published: 1 August 2007
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Authors |
| Ashkan Vaziri | |
| Division of Engineering and Applied
Sciences Harvard University Cambridge, MA 02138 United States |
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| http://www.deas.harvard.edu/~avaziri | |
| Arvind Gopinath | |
| Division of Engineering and Applied
Sciences Harvard University Cambridge, MA 02138 United States |
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| Vikram S. Deshpande | |
| Engineering Department Cambridge University Trumpington Street Cambridge, CB2 1PZ United Kingdom |
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