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Evaluating corneal biomechanics using interocular pressure methods and making surrogate models: sensitivity analysis and parametric optimization

Pouria Mazinani, Hamed Setayesh Nasab, Daria Scerrato and Alberto Bersani
Vol. 14 (2026), No. 2, 229–256
DOI: 10.2140/memocs.2026.14.229
Abstract

The Corvis tonometer is widely used to measure intraocular pressure in the cornea and contact lens. In this study, based on the results of finite element simulations from a previous study, the methodology for generating two types of metamodels is elaborated in detail, and the challenges associated with each is examined. In addition, the sensitivity of each metamodel category to its inputs is analyzed, and the influence of each parameter is thoroughly evaluated. The results show that, even under significant variations in the inputs, the changes in this parameter remain minimal, making it a worthy measure for estimating the projected pressure.

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Keywords
corneal, interocular pressure methods, surrogate models, parametric optimization
Mathematical Subject Classification
Primary: 74-10
Milestones
Received: 1 November 2025
Revised: 22 December 2025
Accepted: 6 January 2026
Published: 19 March 2026

Communicated by Mario Spagnuolo
Authors
Pouria Mazinani
Department of Civil Engineering and Architecture
University of Catania
Catania
Italy
Hamed Setayesh Nasab
Department of Mechanical Engineering
Isfahan University of Technology
Isfahan
Iran
Daria Scerrato
Department of Mechanical and Aerospace Engineering
University of Rome La Sapienza
Rome
Italy
Alberto Bersani
Department of Mechanical and Aerospace Engineering
University of Rome La Sapienza
Rome
Italy
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