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Evaluating
corneal biomechanics using interocular pressure methods and
making surrogate models: sensitivity analysis and parametric
optimization
Pouria Mazinani, Hamed Setayesh Nasab, Daria Scerrato and Alberto Bersani |
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Vol. 14 (2026), No. 2, 229–256
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Abstract |
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The Corvis tonometer is widely used to measure intraocular pressure in the cornea and contact lens. In this study, based on the results of finite element simulations from a previous study, the methodology for generating two types of metamodels is elaborated in detail, and the challenges associated with each is examined. In addition, the sensitivity of each metamodel category to its inputs is analyzed, and the influence of each parameter is thoroughly evaluated. The results show that, even under significant variations in the inputs, the changes in this parameter remain minimal, making it a worthy measure for estimating the projected pressure. |
Keywords
corneal, interocular pressure methods, surrogate models,
parametric optimization
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Mathematical Subject Classification
Primary: 74-10
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Milestones
Received: 1 November 2025
Revised: 22 December 2025
Accepted: 6 January 2026
Published: 19 March 2026
Communicated by Mario Spagnuolo
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Authors |
| Pouria Mazinani | |
| Department of Civil Engineering and
Architecture University of Catania Catania Italy |
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| Hamed Setayesh Nasab | |
| Department of Mechanical
Engineering Isfahan University of Technology Isfahan Iran |
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| Daria Scerrato | |
| Department of Mechanical and
Aerospace Engineering University of Rome La Sapienza Rome Italy |
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| Alberto Bersani | |
| Department of Mechanical and
Aerospace Engineering University of Rome La Sapienza Rome Italy |
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| © 2026 MSP (Mathematical Sciences Publishers). |
