We consider the problem of
deciding whether or not a given group G has a Wirtinger presentation, i.e., a
presentation in which each defining relation states that two generators are conjugate
or that a generator commutes with some word. This property is important because it
characterizes those groups that can be realized as knot groups of closed,
orientable n-manifolds in Sn+2. We isolate the obstruction in the form of
an abelian group somewhat related to H2(G). We do this by considering
Wirtinger-presented groups that are approximations to G and prove the existence of
a best-approximation.