We extend Voiculescu’s
microstates-free definitions of free Fisher information and free entropy to the
non-tracial framework. We explain the connection between these quantities and free
entropy with respect to certain completely positive maps acting on the core of the
non-tracial non-commutative probability space. We give a condition on free Fisher
information of an infinite family of variables, which guarantees factoriality of the von
Neumann algebra they generate.